Thermo Fisher Scientific STK38 Monoclonal Antibody (2G8-1F3)
인간 STK38 단백질을 인식하는 Thermo Fisher Scientific의 mouse monoclonal antibody입니다. Western blot과 ELISA에 사용 가능하며, 액상 형태로 제공됩니다. -20°C 보관하며, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific STK38 Monoclonal Antibody (2G8-1F3)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G8-1F3 |
| Immunogen | STK38 (AAH12085, 1–465 a.a.) full-length recombinant protein with GST tag (MW of GST tag = 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAMTGSTPCS SMSNHTKERV TMTKVTLENF SSNLIAQHEE REMRQKKLEK VMEEEGLKDE EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS EKAKDLILRF CCEWEHRIGA PGVEEIKSNS FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK PTVAISNHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAAK
Target Information
STK38 (also known as NDR) or Nuclear Dbf2-related protein is a serine/threonine kinase belonging to the AGC kinase family, regulated by Mob proteins.
Fas and TNFα receptor stimulation activates human STK38 through phosphorylation at the hydrophobic motif.
NDR acts as a pro-apoptotic kinase and is a key component of the RASSF1A/MST1 signaling cascade.
STK38 is essential for mitotic chromosome alignment fidelity and is incorporated into HIV-1 particles, where it is cleaved by HIV-1 protease.
STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is reduced upon STK38 activity inhibition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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