Thermo Fisher Scientific Sodium/Hydrogen Exchanger 1 Polyclonal Antibody, Biotin
Sodium/Hydrogen Exchanger 1 단백질을 인식하는 Biotin-conjugated Rabbit Polyclonal Antibody. Western blot, ELISA, IP에 적합하며, 다양한 종(Human, Mouse, Rat 등)에 반응합니다. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공합니다.
- 카탈로그번호
- NHE1-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 700–750 of human Sodium/Hydrogen Exchanger 1 (SLC9A1) protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) containing 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic) / Wet ice (international) |
Target Information
The Na⁺/H⁺ antiporter (Nhe-1) is a membrane-bound enzyme critical for pH regulation in vertebrate cells. It is inhibited by the diuretic drug amiloride and activated by growth factors, mitogens, neurotransmitters, and tumor promoters.
Nhe-1 also serves as an anchor for actin filaments via interaction with ERM proteins (ezrin, radixin, moesin), maintaining cortical cytoskeleton integrity.
It may have structural roles independent of ion exchange and is implicated in hypertension. Multiple isoforms of Nhe-1 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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