Thermo Fisher Scientific Human IRF8 Synthetic Peptide
Human IRF8 단백질의 카복시 말단 16개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. IRF8 항체의 블로킹 펩타이드로 사용 가능하며, 정제된 액상 형태로 제공됩니다. PBS(pH 7.2)와 BSA를 포함하며, -20°C에서 보관합니다.
- 카탈로그번호
- PEP0206
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the carboxy terminus of human IRF8.
PEP-0206 can be used as a blocking peptide with polyclonal antibody PA5-20088.
Target Information
IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes.
IRF8 plays a negative regulatory role in immune system cells and is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer. This leads to recognition of the AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of target genes.
Mutations in the IRF8 gene can result in immunodeficiency 32A and 32B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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