Thermo Fisher Scientific Human Btk Synthetic Peptide
Human BTK 단백질의 아미노 말단 16개 아미노산 서열을 기반으로 한 합성 펩타이드. 항체 PA5-20085와 함께 차단(Blocking) 실험에 사용 가능. 정제된 액상 형태로 제공되며, PBS(pH 7.2) 및 0.1% BSA 포함. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human BTK (NT).
PEP-0203 can be used as a blocking peptide with polyclonal antibody PA5-20085.
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases.
Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders.
It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9.
The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens.
BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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