Thermo Fisher Scientific Phospho-PRAS40 (Thr246) Recombinant Superclonal Antibody (8HCLC)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of a defined mixture of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.
These antibodies recognize multiple epitopes on the target protein, providing enhanced detection sensitivity for low-abundance targets.
Unlike traditional polyclonal antibodies, the recombinant Superclonal™ format ensures lot-to-lot reproducibility by using a known combination of light and heavy chain sequences.
Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The product and performance remain unchanged.

Target Information

The Akt signaling pathway regulates apoptosis in response to various cell death signals. AKT1S1 (PRAS40) is a proline-rich substrate of AKT1 and is implicated in neuroprotection mediated by nerve growth factor (NGF) following transient focal cerebral ischemia.
PRAS40 also acts as a substrate and potential regulator of the mammalian target of rapamycin (mTOR), a serine/threonine kinase involved in cell growth, cell cycle regulation, and autophagy inhibition.
Insulin-like growth factor-1 (IGF1) treatment induces phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.