Thermo Fisher Scientific Phospho-AMPK alpha-1,2 (Thr183, Thr172) Recombinant Superclonal Antibody (10HCLC)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse, rat, non-human primate, and Drosophila based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They combine multiple recombinant monoclonal antibodies, providing the sensitivity of polyclonal antibodies and the specificity and consistency of monoclonal antibodies.
Each lot is produced with a defined mixture of light and heavy chains, ensuring reproducibility and eliminating biological variability typical of polyclonal antibody production.

Note: Formerly called “Recombinant Polyclonal Antibody”, this product is now rebranded as “Recombinant Superclonal™ Antibody”. The physical product and performance remain unchanged.

Target Information

The encoded protein is a catalytic subunit of AMP-activated protein kinase (AMPK), a heterotrimeric enzyme complex consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits.
AMPK acts as an energy sensor that regulates cellular metabolism. Upon activation by metabolic stress, AMPK phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), key enzymes in fatty acid and cholesterol biosynthesis.
In mouse models, this subunit has been shown to influence insulin sensitivity and maintain myocardial energy homeostasis during ischemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.