Thermo Fisher Scientific NSE Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Neuron specific enolase (NSE, ENO1, ENO2, ENO3) is an enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. NSE is highly stable in biological fluids and diffuses into extracellular medium and cerebrospinal fluid (CSF) when neuronal membranes are damaged.

NSE is one of three mammalian enolases (ENO1, ENO2, ENO3), also known as enolase α, β, and γ. The α-subunit is expressed in most tissues, the β-subunit in muscle, and the γ-subunit primarily in neurons and neuroendocrine cells. Co-expression of NSE and chromogranin A is common in neuroendocrine neoplasms.

Antibodies to NSE are useful for identifying neuronal cell bodies, developing neuronal lineages, and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood serves as a biomarker of neuronal injury. Clinically, NSE is a sensitive marker for neuronal damage in disorders such as stroke, hypoxic brain injury, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis. Elevated NSE levels are also observed in plasma and certain neoplasias, including pediatric neuroblastoma and small cell lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.