Thermo Fisher Scientific Phospho-CHK2 (Ser516) Polyclonal Antibody
인간 CHK2 단백질의 Ser516 인산화 부위를 인식하는 rabbit polyclonal 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 교차 반응성이 낮고 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer516 of human Chk2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979955 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with Chk2 phosphorylated at other sites.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are linked to various cancers. CHK2 is activated by DNA damage and phosphorylates several cell cycle regulators, including tumor suppressor proteins. It can also phosphorylate BRCA1, facilitating DNA damage repair. CHK2 acts as a tumor suppressor, and mutations are associated with Li-Fraumeni syndrome and predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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