Thermo Fisher Scientific ADSL Polyclonal Antibody
ADSL 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도의 Affinity chromatography 정제 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within N-terminal human AMPS (ADSL, UniProt ID: P30566-1, 1–484 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913367 |
Product Specific Information
- Positive Control: Jurkat cell lysate, NIH/3T3 cell lysate, mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate, mouse brain tissue
- Subcellular Location: Cytosol
Target Information
ADSL (adenylosuccinate lyase), also known as AMPS, ASL, or ASASE, is a 484 amino acid enzyme involved in purine biosynthesis and AMP formation from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: removal of fumarate from succinylaminoimidazole carboxamide ribotide (SAICA ribotide) to yield aminoimidazole carboxamide ribotide (AICA ribotide), and removal of fumarate from adenylosuccinate to form AMP.
Mutations in the ADSL gene cause adenylosuccinase deficiency, an autosomal recessive disorder characterized by epilepsy, growth retardation, and muscular wasting. Multiple isoforms exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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