Thermo Fisher Scientific OXER1 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal OXER1 항체. Western blot 및 Immunocytochemistry에 사용 가능. 합성 펩타이드(aa 220–270)로부터 유래된 면역원 사용. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human OXER1 (Accession Q8TDS5), corresponding to amino acid residues I220–F270 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851707 |
Product Specific Information
Antibody detects endogenous levels of total OXER1.
Target Information
TG1019 is a G protein-coupled receptor that functions as a chemoattractant for eosinophils and neutrophils. TG1019 is expressed in various tissues except the brain, with the highest expression in liver, kidney, peripheral leukocyte, lung, and spleen. TG1019 interacts with the protein OXE to form TG1019/OXE, a Galpha i/o protein-coupled receptor. Signals from TG1019 are transduced via a Galpha i/o protein to PLC/calcium, MEK/ERK, and PI3K/Akt pathways. Stimulation with 5-oxo-6E,8Z,11Z,14Z eicosatetraenoic acid (5-oxo-ETE) induces intracellular calcium mobilization and rapid activation of MEK/ERK and PI3K/Akt pathways. TG1019 may also play a role in downregulating cAMP production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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