Thermo Fisher Scientific HDAC9 Monoclonal Antibody (OTI7G9), TrueMAB

Thermo Fisher Scientific HDAC9 Monoclonal Antibody (OTI7G9), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

In cells, DNA associates with histones and nuclear proteins to form chromatin. Chromatin remodeling, driven by histone acetylation, regulates transcriptional activity. Acetylation of histone lysine residues alters nucleosomal conformation, increasing DNA accessibility for transcription factors.
Histone deacetylases (HDACs) reverse this process, leading to transcriptional silencing. HDAC9 and HDAC9a are alternatively spliced isoforms containing catalytic domains responsible for deacetylase activity and repression of myocyte enhancer-binding factor 2-mediated transcription. Both isoforms are expressed in brain, skeletal muscle, kidney, placenta, and pancreas.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.