Thermo Fisher Scientific Tankyrase Polyclonal Antibody
Tankyrase 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 고농도(0.96 mg/mL) 액상 형태로 제공되며, 인간 및 다양한 종에 높은 반응 예측. 연구용으로 Wnt 신호전달 및 텔로미어 조절 연구에 적합.
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Thermo Fisher Scientific Tankyrase Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 1070–1303 of Human Tankyrase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.96 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548344 |
Product Specific Information
- Recommended positive control: MCF-7
- Predicted reactivity: Human (99%), Mouse (99%), Rat (98%), Xenopus laevis (97%), Chicken (98%), Rhesus Monkey (99%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length regulation, and vesicle trafficking.
Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, key components of the beta-catenin destruction complex.
Mediates PARsylation of BLZF1, CASC3, TERF1, and HEPACAM2/MIKI, contributing to telomere length regulation and centrosome maturation.
May regulate vesicle trafficking and modulate SLC2A4/GLUT4-vesicle distribution.
Also involved in spindle pole assembly through PARsylation of NUMA1 and stimulates 26S proteasome activity.
[UniProt]
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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