Thermo Fisher Scientific LIN7A Polyclonal Antibody
LIN7A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 인간 및 마우스 반응성. 고순도 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–227 of Human LIN7A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548345 |
Product Specific Information
- Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (97%), Bovine (100%)
- Store as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
LIN7A plays a role in establishing and maintaining asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
It forms membrane-associated multiprotein complexes that regulate delivery and recycling of proteins to correct membrane domains.
The tripartite complex composed of LIN7 (LIN7A, LIN7B, LIN7C), CASK, and APBA1 may couple synaptic vesicle exocytosis to cell adhesion in the brain.
Ensures proper localization of GRIN2B to neuronal postsynaptic density and may localize synaptic vesicles at synapses via beta-catenin and cadherin interactions.
Required for localization of Kir2 channels, GABA transporter (SLC6A12), and EGFR/ERBB family receptors to the basolateral membrane of epithelial cells.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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