Thermo Fisher Scientific CD18 Monoclonal Antibody (10E12)
CD18 단백질을 표적하는 Mouse IgG2b 단클론 항체로, 인간 및 생쥐 시료에 반응합니다. ELISA와 면역형광(ICC/IF)에 적합하며, 세포 부착 및 신호전달 연구에 활용됩니다. 액상 형태로 제공되며, 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10E12 |
| Immunogen | Purified recombinant fragment of CD18 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% Sodium Azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet Ice |
| RRID | AB_10984783 |
Product Specific Information
MA5-15517 targets CD18 in indirect ELISA and IF applications, showing reactivity with human and mouse samples.
The immunogen is a purified recombinant fragment of CD18 expressed in E. coli.
MA5-15517 detects CD18 with a predicted molecular weight of approximately 85 kDa.
Target Information
CD18 (integrin beta 2 subunit) is a 90 kDa type I transmembrane protein expressed on all leukocytes.
It forms heterodimers with CD11 molecules (CD11a–d) to constitute leukocyte β2 integrins:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins are essential for proper leukocyte migration and intercellular adhesion.
Deficiency or reduction in CD18 expression leads to leukocyte adhesion deficiency type I (LAD1) and may cause psoriasiform skin disease.
CD18 is also a receptor for Mannheimia haemolytica leukotoxin, mediating leukotoxin-induced cytolysis.
Two transcript variants encoding the CD18 protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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