Thermo Fisher Scientific PRR5L Polyclonal Antibody
PRR5L 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 최적화. Human과 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체. 연구용으로만 사용 가능.
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Thermo Fisher Scientific PRR5L Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the center of human PRR5L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154689 |
Product Specific Information
- Suggested positive control: NIH-3T3 cell lysate
- PA5-21129 can be used with blocking peptide PEP-1243
Target Information
Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and binds to the mTOR complex 2 (mTORC2).
PRR5L is not required for mTORC2 integrity or kinase activity but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2.
Knockdown of PRR5L reduces apoptosis in mTORC2-deficient cells as well as cells where mTOR is active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis and play a role in the balance between cell growth and cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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