Thermo Fisher Scientific SF1 Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunoprecipitation (IP)

• 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Mouse

Target Information

Splicing factor 1 (SF1) is a nuclear pre-mRNA splicing factor that specifically recognizes the intron branch point sequence at the 3′ splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for early spliceosome assembly. It also plays roles in nuclear pre-mRNA retention and transcriptional repression. The protein contains:

• N-terminal U2AF ligand motif
• Central hnRNP K homology motif and quaking 2 region (binds branch-site adenosine)
• Zinc knuckles domain
• C-terminal proline-rich domain

Alternative splicing results in multiple transcript variants.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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