Thermo Fisher Scientific MDMX VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1189)
Alpaca VHH 기반의 재조합 단일클론 항체로, 인간 MDMX 단백질을 표적합니다. Direct ELISA에 적합하며, CHO 세포에서 발현되었습니다. 1 mg/mL 농도의 액상 형태로 PBS에 보존되며, 금속 킬레이트 크로마토그래피로 정제되었습니다.
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Applications
- ELISA (ELISA): Assay-dependent
- Compatible with Direct ELISA
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1189 |
| Immunogen | Recombinant Human MDM4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus. This sequestration of MDMX by ARF results in an increase in p53 transactivation. In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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