Thermo Fisher Scientific AMPK beta-1 Monoclonal Antibody (H.743.5)
AMPK 베타-1 단백질을 인식하는 Rabbit 모노클로날 항체로, Western Blot에 최적화됨. 인간, 생쥐, 햄스터 등 다양한 종에 반응. 에너지 대사 관련 연구용으로 사용되며, 교차 반응 없음. 액상 형태로 -20°C 보관.
- 카탈로그번호
- MA514945
- 판매단위
- pk
카탈로그
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Applications
Tested Application
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Non-human primate, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H.743.5 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Val176 of human AMPKβ1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10977804 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other related proteins.
Target Information
AMPK beta 1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits.
AMPK functions as an energy-sensing enzyme that monitors cellular energy status. In response to metabolic stress, AMPK becomes activated and phosphorylates key enzymes such as acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), thereby regulating fatty acid and cholesterol biosynthesis.
The beta-1 subunit may positively regulate AMPK activity and serve as an adaptor molecule mediating complex association. Myristoylation and phosphorylation of this subunit influence AMPK enzyme activity and localization.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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