Thermo Fisher Scientific NMDAR2B Polyclonal Antibody
NMDAR2B 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, IP에 사용 가능. NR2A와 교차 반응 없음. Affinity chromatography로 정제된 Lyophilized 형태이며, 인간, 마우스, 랫트 시료에 반응. 신경 발달 및 학습 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Immunoprecipitation (IP) | 3 µL/200 µg lysate | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein from the C-terminal region of the NR2B subunit of rat GRIN2B |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Affinity chromatography |
| Storage Buffer | Whole serum, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325652 |
Product Specific Information
- This antibody shows no cross-reactivity with NR2A subunit.
- Reconstitute with 50 µL of PBS.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency related to memory and learning.
NMDARs play a role in neuronal development and are implicated in disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Overexpression of the NR2B subunit is associated with enhanced learning and memory, while reduced NR2B expression is observed in aged, memory-impaired animals.
Phosphorylation of Tyr1472 on NR2B may increase synaptic expression of NMDAR, contributing to synaptic plasticity. NMDR2B forms a heterotrimer with NR1, NR2, and NR3 subunits. Dysfunction of NMDAR2B is linked to epileptic encephalopathy and autosomal dominant 6-related mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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