Thermo Fisher Scientific NMDAR2C Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• View 4 publications

Immunoprecipitation (IP)

• Tested Dilution: 3 µL / 200 µg lysate

Product Specifications

Product Specific Information

This antibody detects predominantly the NR2C isoform but may show low-level cross-reactivity with the NR2A and NR2B isoforms.
In Western blot, this antibody detects a ~140 kDa protein representing NR2C in rat brain homogenate. Faint bands representing the NR2A and NR2B isoforms at 180 kDa may also be observed.
Immunohistochemical staining in rat brain with OPA1-04020 yields a pattern consistent with plasma membrane staining.
Reconstitute with 50 µL of PBS.

Target Information

The NMDA Receptor (NMDAR) plays an essential role in memory and neuronal development. It is implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
NMDAR is a principal molecular target for alcohol in the CNS and is potentiated by protein phosphorylation.
The NR1 protein can form NMDA-activated channels when expressed in Xenopus oocytes, but the currents in such channels are smaller than those observed in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: OPA1-04020_NMDAR2C_Q00961-1_Rabbit.svg, OPA1-04020_NMDAR2C_Q00961-1_Rabbit_PDP.jpeg)