Thermo Fisher Scientific NMDAR2C Polyclonal Antibody
NMDAR2C 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. NR2C isoform에 높은 특이성을 가지며 NR2A/B와 약한 교차 반응을 보입니다. Lyophilized 형태로 제공되며 -20°C에서 보관합니다.
- 카탈로그번호
- OPA104020
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 4 publications
Immunoprecipitation (IP)
- Tested Dilution: 3 µL / 200 µg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein from the N-terminal region of the NR2C subunit of rat GRIN2C |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 5 mM Ammonium bicarbonate, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2112587 |
Product Specific Information
This antibody detects predominantly the NR2C isoform but may show low-level cross-reactivity with the NR2A and NR2B isoforms.
In Western blot, this antibody detects a ~140 kDa protein representing NR2C in rat brain homogenate. Faint bands representing the NR2A and NR2B isoforms at 180 kDa may also be observed.
Immunohistochemical staining in rat brain with OPA1-04020 yields a pattern consistent with plasma membrane staining.
Reconstitute with 50 µL of PBS.
Target Information
The NMDA Receptor (NMDAR) plays an essential role in memory and neuronal development. It is implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
NMDAR is a principal molecular target for alcohol in the CNS and is potentiated by protein phosphorylation.
The NR1 protein can form NMDA-activated channels when expressed in Xenopus oocytes, but the currents in such channels are smaller than those observed in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: OPA1-04020_NMDAR2C_Q00961-1_Rabbit.svg, OPA1-04020_NMDAR2C_Q00961-1_Rabbit_PDP.jpeg)
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