Thermo Fisher Scientific P2Y14 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 11 µg/mL

Product Specifications

Product Specific Information

By immunohistochemistry, OPA1-15556 detects GPR105 in formalin-fixed, paraffin-embedded human tissues.

Target Information

GPR105 has been reported to be expressed in the brain. ESTs have been isolated from kidney, placenta, uterus, and heart/melanocyte/uterus libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs, leading to signaling via G-proteins and downstream effectors.
Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs.
This "turn-off" activity has tremendous implications for the physiological action of the cell and continues to drive pharmacological research for new drug candidates.
Two GPCR-targeted pharmaceuticals, Zyprexa (Eli Lilly) and Claritin (Schering-Plough), hold multi-billion dollar shares in the mental health and allergy markets, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.