Thermo Fisher Scientific P2Y14 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GPR105 (P2Y14), suitable for IHC (Paraffin) applications. Detects GPR105 in formalin-fixed tissues. Supplied as liquid, unconjugated, 1 mg/mL concentration. For research use only; store at 4°C short term or -2...
- 카탈로그번호
- OPA115556
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 11 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide, KLH conjugated, corresponding to the 2nd extracellular domain of human G Protein-Coupled Receptor GPR105 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2155991 |
Product Specific Information
By immunohistochemistry, OPA1-15556 detects GPR105 in formalin-fixed, paraffin-embedded human tissues.
Target Information
GPR105 has been reported to be expressed in the brain. ESTs have been isolated from kidney, placenta, uterus, and heart/melanocyte/uterus libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs, leading to signaling via G-proteins and downstream effectors.
Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs.
This "turn-off" activity has tremendous implications for the physiological action of the cell and continues to drive pharmacological research for new drug candidates.
Two GPCR-targeted pharmaceuticals, Zyprexa (Eli Lilly) and Claritin (Schering-Plough), hold multi-billion dollar shares in the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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