Thermo Fisher Scientific Phospho-HPK1 (Ser171) Polyclonal Antibody
Phospho-HPK1 (Ser171) 폴리클로날 항체로, 인간 HPK1 단백질의 인산화 형태를 검출합니다. Western blot에 최적화되어 있으며, Rabbit IgG 호스트로 제작되었습니다. MAP4K1 신호전달 연구 및 T세포 활성 조절 연구에 활용 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S171 of human MAP4K1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980504 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
MAP4K1 (also known as HPK1, Hematopoietic progenitor kinase 1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase superfamily.
MAP4K1 acts as a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway, diminishing T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76.
JNKs/SAPKs play a crucial role in stress responses in mammalian cells. HPK1 is expressed predominantly in hematopoietic cells, including early progenitors, and specifically activates JNK1 and AP-1-mediated transcriptional activity.
HPK1 binds and phosphorylates MEKK1 directly, and JNK1 activation by HPK1 is inhibited by dominant-negative MEKK1 or MKK4/SEK mutants. Unlike PAK65, HPK1 does not bind Rac1 or Cdc42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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