Thermo Fisher Scientific Phospho-PAK1/2/3 (Ser144, Ser141, Ser139) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated PAK1/2/3 (Ser144, Ser141, Ser139). Validated for Western blot at 1:1,000 dilution. Predicted to react with mouse and rat samples. Supplied as unconjugated liquid form at 1 mg/mL, stored at -20°C.
- 판매단위
- pk
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Applications
Tested Application and Dilution
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PAK1/2/3 around the phosphorylation site of Ser144, Ser141, Ser139 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691676 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
In mammals, several isoforms of p21-Activated Protein Kinases (PAKs) are identified:
- α-PAK (PAK-1) and β-PAK (PAK-3) are mostly brain-specific.
- γ-PAK (PAK-2) is expressed ubiquitously (Jakobi et al., 2003).
Mutations in the gene coding for PAK-3 are associated with X-linked mental retardation.
PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004).
It plays a crucial role in regulation of cell shape, motility, and cell death (Jakobi et al., 2003; Walter et al., 1998).
Autophosphorylation of Thr402 is essential for activation of PAK (Jakobi et al., 2000).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-67511_PAK123_Q13153-1_Rabbit_PDP.jpeg, PA5-67511_PAK123_O75914-1_Rabbit_PDP.jpeg, PA5-67511_PAK123_Q13177-1_Rabbit_PDP.jpeg)
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