Thermo Fisher Scientific Phospho-PAK1/2/3 (Ser144, Ser141, Ser139) Polyclonal Antibody

Applications

Tested Application and Dilution

• Western Blot (WB): 1:1,000

Product Specifications

Product Specific Information

Predicted to react with Mouse and Rat samples.

Target Information

In mammals, several isoforms of p21-Activated Protein Kinases (PAKs) are identified:

• α-PAK (PAK-1) and β-PAK (PAK-3) are mostly brain-specific.
• γ-PAK (PAK-2) is expressed ubiquitously (Jakobi et al., 2003).

Mutations in the gene coding for PAK-3 are associated with X-linked mental retardation.
PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004).
It plays a crucial role in regulation of cell shape, motility, and cell death (Jakobi et al., 2003; Walter et al., 1998).
Autophosphorylation of Thr402 is essential for activation of PAK (Jakobi et al., 2000).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-67511_PAK123_Q13153-1_Rabbit_PDP.jpeg, PA5-67511_PAK123_O75914-1_Rabbit_PDP.jpeg, PA5-67511_PAK123_Q13177-1_Rabbit_PDP.jpeg)