Thermo Fisher Scientific MBP Monoclonal Antibody (Clone 2)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: Assay-dependent

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

MA1-24988 detects Myelin Basic Protein from human, rat, bovine, guinea pig, rabbit, and ovine samples.

Target Information

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called Golli-MBP) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to two sets of MBP-related transcripts and gene products.

The Golli mRNAs contain three exons unique to Golli-MBP, spliced in-frame to one or more MBP exons. They encode hybrid proteins that have N-terminal Golli amino acid sequence linked to MBP amino acid sequence. The second family of transcripts contain only MBP exons and produce the well-characterized myelin basic proteins. This complex gene structure is conserved among species, suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.