Thermo Fisher Scientific MBP Monoclonal Antibody (26)

Applications

• Immunohistochemistry (Frozen) (IHC (F)): Assay-dependent

Product Specifications

Product Specific Information

MA1-24991 detects Myelin Basic Protein from human samples.

Target Information

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. MBP-related transcripts are also present in bone marrow and the immune system, arising from the long MBP gene (Golli-MBP) that contains three additional upstream exons. Alternative splicing from Golli and MBP transcription start sites produces two sets of MBP-related transcripts and proteins:

• Golli mRNAs: contain unique Golli-MBP exons spliced in-frame to MBP exons, encoding hybrid proteins with N-terminal Golli and MBP sequences.
• MBP mRNAs: contain only MBP exons, encoding the well-characterized myelin basic proteins.

This conserved gene structure suggests that the MBP transcription unit is part of the Golli transcription unit, important for their functional and regulatory roles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.