Thermo Fisher Scientific NOX4/NADPH Oxidase 4 Monoclonal Antibody (NOX4, 1245)
인간 NOX4 단백질을 인식하는 Mouse IgG2b 모노클로날 항체입니다. Western blot에 최적화되어 있으며, 단백질 A/G로 정제된 액상 형태입니다. 산소 감지 및 ROS 신호 전달 연구에 적합합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific NOX4/NADPH Oxidase 4 Monoclonal Antibody (NOX4, 1245)
Applications
- Western Blot (WB): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NOX4, 1245 |
| Immunogen | Recombinant human NOX4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Antibody is tested in direct ELISA.
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex.
NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells.
Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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