Thermo Fisher Scientific MARCO Polyclonal Antibody
Rabbit polyclonal antibody targeting human MARCO protein. Validated for Western blot. Recognizes membrane-associated MARCO involved in immune response and cancer immunotherapy research. Supplied as liquid, unconjugated form, 1.97 mg/mL, stored at -20°C.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 421–520 of human MARCO |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.97 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804276 |
Product Specific Information
- Immunogen sequence: SVSVRIVGSS NRGRAEVYYS GTWGTICDDE WQNSDAIVFC RMLGYSKGRA LYKVGAGTGQ IWLDNVQCRG TESTLWSCTK NSWGHHDCSH EEDAGVECSV
- Positive Samples: A-549, K-562, Mouse spleen, Rat liver
- Cellular Location: Membrane, Single-pass type II membrane protein
Target Information
MARCO (Macrophage Receptor with Collagenous Structure), also known as SR-A6 or SCARA2, is a macrophage surface receptor and a member of the class A scavenger receptor family.
It binds both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal scavenger receptor cysteine-rich (SRCR) domain.
The protein includes short cytoplasmic and transmembrane domains, an extracellular spacer domain, and a long collagenous domain that can form trimeric structures.
Due to its expression in tumor-infiltrating macrophages and its immunosuppressive role in the tumor microenvironment, MARCO is considered a potential target for cancer immunotherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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