Thermo Fisher Scientific MPP10 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 432-681 of human MPHOSPH10 (NP_0057821) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MPP10,uniProtId:O00566-1,ncbiNodeId:9606,antigenRange:432-681,antigenLength:681,antigenImageFileName:PA5-87589_MPP10_O00566-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87589_MPP10_O00566-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.42 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804272

Product Specific Information

Immunogen sequence: RIRDQAWDDV VRKEKPKEDA YEYKKRLTLD HEKSKLSLAE IYEQEYIKLN QQKTAEEENP EHVEIQKMMD SLFLKLDALS NFHFIPKPPV PEIKVVSNLP AITMEEVAPV SVSDAALLAP EEIKEKNKAG DIKTAAEKTA TDKKRERRKK KYQKRMKIKE KEKRRKLLEK SSVDQAGKYS KTVASEKLKQ LTKTGKASFI KDEGKDKALK SSQAFFSKLQ DQVKMQINDA KKTEKKKKKR QDISVHKLKL; Positive Samples: MCF-7, HeLa; Cellular Location: Chromosome, Nucleus, nucleolus

Target Information

MPP10 (M-phase phosphoprotein 10), also known as MPHOSPH10, is a 681 amino acid protein that localizes to the fibrillar region of the nucleolus. Phosphorylated in the M (mitotic) phase of the cell cycle, MPP10 is a component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex and is required for the early cleavages during pre-18S ribosomal RNA processing. MPP10 forms a heterotrimeric complex with IMP-3 and IMP-4, which may be required for its association with nucleolar components. The gene encoding MPP10 is localized to human chromosome 2, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.