Thermo Fisher Scientific TPO (Thyroid Peroxidase) Monoclonal Antibody (TPO, 3700)
인체 TPO 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, IHC(P) 및 Peptide Array에 사용 가능. 고순도 Protein A/G 정제, 액상 형태로 제공. PBS 기반 저장용액과 sodium azide 포함, 4°C 보관. 갑상선 기능 관련 연구용에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TPO, 3700 |
| Immunogen | Recombinant fragment of human TPO (around aa 685–804) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed):
Incubate antibody for 30 min at room temperature (RT).
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 min.
Target Information
Thyroid Peroxidase (TPO) is a membrane-bound glycoprotein enzyme essential for thyroid gland function.
It catalyzes iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester bonds between iodinated tyrosines, leading to production of thyroid hormones such as thyroxine (T4) and triiodothyronine (T3).
Mutations in TPO can cause disorders including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.
Several transcript variants encoding distinct isoforms have been identified, though some full-length forms remain undetermined.
Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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