Thermo Fisher Scientific TPO (Thyroid Peroxidase) Monoclonal Antibody (TPO, 3700)
인간 TPO 단백질을 인식하는 Mouse monoclonal 항체로, IHC(P) 및 Peptide Array에 사용 가능. Recombinant human TPO(aa 685-804)로부터 유래. Protein A/G 정제, 1 mg/mL 농도, PBS(pH 7.4) 용액 형태. 연구용으로만 사용 가능.
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- 7173-MSM10-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TPO, 3700 |
| Immunogen | Recombinant fragment of human TPO (around aa 685–804) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed):
Incubate antibody for 30 minutes at room temperature.
For formalin-fixed tissues, heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Thyroid Peroxidase (TPO) is a membrane-bound glycoprotein enzyme essential for thyroid gland function.
It catalyzes the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester bonds between iodinated tyrosines, leading to the synthesis of thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Mutations in the TPO gene are associated with disorders such as congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.
Multiple transcript variants encoding distinct isoforms have been identified, although some full-length variants remain undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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