Thermo Fisher Scientific c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Epitope sequence: EQKLISEEDL, located in aa 410–419 of human c-Myc protein.

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and regulation. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy termini of target proteins. c-Myc-, N-Myc-, and L-Myc-encoded proteins function in cell proliferation, differentiation, and neoplastic disease.

Amplification or translocation of the c-Myc gene has been found in lung, breast, colon carcinomas, and Burkitt’s lymphoma, among other B-cell lymphoproliferative conditions. Aberrant expression occurs in tumors from various origins such as colorectal, gastric, hepatic, ovarian, pulmonary, and hematopoietic neoplasms.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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