Thermo Fisher Scientific Blood Group Antigen Lewis B Monoclonal Antibody (SPM194)
Lewis B 혈액형 항원에 특이적인 단클론 항체로, 인간 및 기니피그 시료에 반응합니다. 면역조직화학(IHC) 및 면역세포화학(ICC/IF)에 사용 가능하며, 고순도 Protein A/G 정제 제품입니다. 연구용으로만 사용되며, -20°C에서 보관합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Guinea pig, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM194 |
| Immunogen | Mucin isolated from a human ovarian cyst fluid |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Target Information
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids. These glycosphingolipids play roles in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells, giving rise to the Lewis phenotype.
This gene belongs to the fucosyltransferase family, catalyzing the addition of fucose to precursor polysaccharides in the final step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)- and alpha(1,4)-fucosyltransferase activities.
Alterations in the Lewis antigen system have been described in gastric carcinoma and related lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: 2525-MSM1X-P1ABX_Blood_Group_Antigen_Lewis_B_P21217-1_House_mouse.svg, 2525-MSM1X-P1ABX_Blood_Group_Antigen_Lewis_B_P21217-1_House_mouse_PDP.jpeg)
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