Thermo Fisher Scientific Blood Group Lewis A Monoclonal Antibody (T174)
인간 Lewis A 혈액형 항원을 인식하는 Mouse IgG1 단일클론 항체로, IHC(P)에서 1:40 희석으로 사용 가능. SK-CO-10 인간 대장암 세포주로부터 유래한 면역원 사용. Protein G 정제 및 PBS + 1% BSA 저장. 연구용으로 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:40
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | T174 |
| Immunogen | SK-CO-10 human colon cancer cell line |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_794768 |
Product Specific Information
- Positive Control: Colon adenocarcinoma (human)
Target Information
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids. These glycosphingolipids play roles in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells, determining the Lewis phenotype.
This gene belongs to the fucosyltransferase family, catalyzing the addition of fucose to precursor polysaccharides in the final step of Lewis antigen biosynthesis. It encodes an enzyme with both alpha(1,3)- and alpha(1,4)-fucosyltransferase activities. Mutations in this gene cause Lewis antigen-negative phenotypes. Multiple alternatively spliced variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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