Thermo Fisher Scientific NMDAR3A/NMDAR3B Monoclonal Antibody (K35/40)
인간 GRIN3A/GRIN3B 단백질을 인식하는 마우스 단일클론 항체로, Western Blot 및 동결면역조직화학에 적합. 고순도 Protein G 정제, 액상 형태, 보존제 무첨가. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1–10 µg/mL
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: 1–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K35/40 |
| Immunogen | Fusion protein corresponding to residues 780–914 from the intracellular III–IV loop of human NR3A + NR3B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_795050 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability, and low voltage-dependent sensitivity to magnesium.
Grin3a is mediated by glycine and may play a role in the development of dendritic spines. It may also be involved in PPP2CB-NMDAR mediated signaling mechanisms.
Grin3a belongs to the superfamily of glutamate-regulated ion channels and functions in physiological and pathological processes in the central nervous system.
Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in knockout mice deficient in Grin3a suggest involvement in synaptic development by modulating NMDA receptor activity.
Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: MA1-26500_NMDAR3ANMDAR3B_O60391-1_House_mouse.svg)
(이미지 파일명: MA1-26500_NMDAR3ANMDAR3B_Q8TCU5-1_House_mouse.svg)
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