Thermo Fisher Scientific NMDAR3A/NMDAR3B Monoclonal Antibody (K35/40)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-10 µg/mL

-

Immunohistochemistry (Frozen) (IHC (F))

1-10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

K35/40

Immunogen

Fusion protein corresponding to residues 780-914 from the intracellular IIIIV loop of human NR3A + NR3B. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NMDAR3A/NMDAR3B,uniProtId:O60391-1,ncbiNodeId:9606,antigenRange:780-914,antigenLength:1043,antigenImageFileName:MA1-26500_NMDAR3ANMDAR3B_O60391-1_House_mouse.svg,antigenImageFileNamePDP:MA1-26500_NMDAR3ANMDAR3B_O60391-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:NMDAR3A/NMDAR3B,uniProtId:Q8TCU5-1,ncbiNodeId:9606,antigenRange:780-914,antigenLength:1115,antigenImageFileName:MA1-26500_NMDAR3ANMDAR3B_Q8TCU5-1_House_mouse.svg,antigenImageFileNamePDP:MA1-26500_NMDAR3ANMDAR3B_Q8TCU5-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.4 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_795050

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Grin3a is mediated by glycine and may play a role in the development of dendritic spines. Further, Grin3a may play a role in PPP2CB-NMDAR mediated signaling mechanism. Grin3a belongs to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in Grin3a suggest that the protein may be involved in the development of synaptic elements by modulating NMDA receptor activity. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.