Thermo Fisher Scientific SIRT1 Recombinant Rabbit Monoclonal Antibody (2H9L18)
SIRT1 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단일클론 항체. ICC/IF 및 ChIP assay에 적합하며, 높은 특이성과 일관된 로트 간 품질을 제공. 인간에 반응하며 원숭이, 돼지, 고양이에서도 예측 반응. 단백질 A로 정제된 액상 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:100 |
| ChIP assay (ChIP) | 2 µg/million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2H9L18 |
| Immunogen | Protein corresponding to human SIRT1 [aa608–aa747] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784594 |
Product Specific Information
This antibody is predicted to react with Monkey, Pig, and Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and coordinates multiple cellular functions such as cell cycle control, DNA damage response, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through histone deacetylation and promotes changes in histone and DNA methylation, leading to transcriptional repression. It plays a crucial role in skeletal muscle differentiation and mediates inhibitory effects on myoblast differentiation in response to nutrient deprivation via AMPK and NAMPT pathways.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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