Thermo Fisher Scientific VPS53 Polyclonal Antibody
Thermo Fisher Scientific의 VPS53 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 액상 항체로, 293 세포 라이세이트를 양성 대조로 권장합니다. HIV 관련 연구 및 GARP 복합체 연구에 활용 가능합니다.
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Thermo Fisher Scientific VPS53 Polyclonal Antibody
Applications
- Western Blot (WB): 0.5–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the center of human VPS53 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156230 |
Product Specific Information
- Suggested positive control: 293 cell lysate
- PA5-20549 can be used with blocking peptide PEP-0669
Target Information
The sorting of acid hydrolases to lysosomes relies on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes.
The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex, composed of VPS52, VPS53, and VPS54.
Depletion of any of these proteins impairs retrograde transport of multiple TGN proteins.
VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry, suggesting potential as a drug target in HIV treatment.
At least five isoforms of VPS53 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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