Thermo Fisher Scientific TNPO3 Polyclonal Antibody
TNPO3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS 버퍼 내 0.02% sodium azide 포함, 2–8°C 보관 권장. 연구용으로 HIV 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the amino terminus of human TNPO3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151881 |
Product Specific Information
- Suggested positive control: Raji cell lysate
- PA5-20550 can be used with blocking peptide PEP-0670.
Target Information
TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins.
This interaction occurs only when the RS domains are phosphorylated.
TNPO3 has been identified as an HIV dependency factor (HDF); depletion of TNPO3 results in HIV inhibition after reverse transcription but before integration, suggesting TNPO3 may be a potential drug target in HIV treatment.
At least three isoforms of TNPO3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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