Thermo Fisher Scientific p14ARF Polyclonal Antibody
Thermo Fisher Scientific의 p14ARF Polyclonal Antibody는 인간 및 랫트 시료에 반응하는 고품질 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS/50% 글리세롤 버퍼에 보관되며 연구용으로만 사용됩니다.
- 카탈로그번호
- PA5115701
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDKN2A (Accession Q8N726), corresponding to amino acid residues L50–G74 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900336 |
Product Specific Information
Antibody detects endogenous levels of total p14 ARF.
Target Information
The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and ARF (p14ARF in human, P19ARF in mouse).
These proteins interact with upstream tumor suppressors — retinoblastoma protein and p53 — and play key roles in cell senescence and tumor suppression pathways.
p14ARF induces G1 and G2 phase arrest depending on functional p53. The functional differences between mouse and human ARF may contribute to species-specific tumor susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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