Thermo Fisher Scientific IL17C Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.3–1 µg/mL
• Publications: N/A

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

Cytokine that plays a crucial role in innate immunity of the epithelium, including response to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A, and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting an inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.