Thermo Fisher Scientific ASCL1 Polyclonal Antibody
ASCL1 단백질을 인식하는 염소 유래 폴리클로날 항체로, 인간, 생쥐, 랫트 반응성. Western blot 및 Immunocytochemistry에 적합. 고순도 액상 형태로 제공되며, 신경발달 및 신경내분비 종양 연구용으로 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-HKSAPKQVKRQRS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933691 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor required for early nervous system development. It is expressed in fetal brain and essential for the development and survival of autonomic neurons. ASCL1 interacts with MEF-2A to regulate genes critical for neuronal circuit formation within the CNS. High ASCL1 expression in neuroendocrine tumors (e.g., medullary thyroid cancer, small cell lung cancer) makes it a useful marker for cancers with neuroendocrine features. The ASCL1 gene maps to human chromosome 12 and contains a trinucleotide repeat region, suggesting potential involvement in inherited diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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