Thermo Fisher Scientific Phospho-PKA beta (Thr198) Polyclonal Antibody
PKA beta 단백질의 Thr198 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot, IHC, ICC 등 다양한 응용에 적합. 사람, 생쥐, 랫드 반응성. 1 mg/mL 농도의 액상 형태로 제공되며 -20°C에서 보관.
- 카탈로그번호
- PA5114622
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRKACB (Accession P22694), corresponding to amino acid residues around phosphorylated Thr198. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899258 |
Product Specific Information
This antibody detects endogenous levels of PKA beta only when phosphorylated at Thr198, which site has been historically referenced as Thr197.
Target Information
The catalytic subunit C-beta of PKA (PRKACB) belongs to the Ser/Thr protein kinase family. The PKA catalytic subunit consists of three gene products: C-alpha, C-beta, and C-gamma, assigned to human chromosome region 1p36.1.
PRKACB is derived from a gene distinct from C-alpha and shows tissue-specific expression. At the amino acid level, C-alpha and C-beta share 93% homology.
The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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