Thermo Fisher Scientific Phospho-PKC mu (Ser205) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous levels of PKD1/PKC mu only when phosphorylated at Ser205.

Target Information

The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. PKC mu activation is dependent on phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지: PA5-114623_PKC_mu_Q15139-1_Rabbit.svg, PA5-114623_PKC_mu_Q15139-1_Rabbit_PDP.jpeg, PA5-114623_PKC_mu_O94806-1_Rabbit.svg, PA5-114623_PKC_mu_O94806-1_Rabbit_PDP.jpeg, PA5-114623_PKC_mu_Q9BZL6-1_Rabbit.svg, PA5-114623_PKC_mu_Q9BZL6-1_Rabbit_PDP.jpeg)