Thermo Fisher Scientific ULBP1 Monoclonal Antibody (3A6F11)
인간 ULBP1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot과 유세포분석(Flow cytometry)에 적합합니다. 비결합형 액상 형태이며, 단백질 G로 정제되어 높은 순도를 제공합니다. ULBP1-NKG2D 상호작용 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:200–1:400
- Publications: 1 publication available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A6F11 |
| Immunogen | Purified recombinant fragment of human ULBP1 (aa 26–216) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898567 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
ULBP1 is a ligand for the NKG2D receptor, along with ULBP2 and ULBP3. These ligands activate multiple signaling pathways in primary NK cells, resulting in cytokine and chemokine production. Binding of ULBP ligands to NKG2D induces calcium mobilization and activates JAK2, STAT5, ERK, and PI3K/Akt signaling pathways.
In CMV-infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16. This interaction blocks binding to NKG2D, allowing CMV-infected cells to evade immune detection. UL16 also retains ULBP1 in the ER and cis-Golgi apparatus, preventing its expression on the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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