Thermo Fisher Scientific UHRF1 Monoclonal Antibody (1A1B1)
UHRF1 단백질을 인식하는 Mouse Monoclonal Antibody로, WB, IHC, ICC, Flow Cytometry, ELISA에 적합. 고순도 Protein G 정제, 1 mg/mL 농도의 액상 형태. Human 시료 반응성, 연구용으로 유전자 발현 조절 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A1B1 |
| Immunogen | Purified recombinant fragment of human UHRF1 (aa: 616–755) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898566 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
The UHRF1 gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. This protein binds to specific DNA sequences and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIα and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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