Thermo Fisher Scientific RAD17 Polyclonal Antibody
효모 RAD17 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관. DNA 손상 반응 및 염색체 안정성 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Yeast |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues S(10) T K R S L K K K K I R K I(23) of the 75 kDa S. pombe RAD17 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_560820 |
Product Specific Information
- PA1-4131 detects yeast RAD17.
- Successfully used in Western blot procedures.
- Detects a ~75 kDa protein representing RAD17 in yeast.
- Immunogen: Synthetic peptide corresponding to residues S(10) T K R S L K K K K I R K I(23) of the 75 kDa S. pombe RAD17.
Target Information
Rad17 is essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage.
It has weak ATPase activity required for chromatin binding and participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, as well as CHEK1 activation.
Rad17 may also serve as a sensor of DNA replication progression and be involved in homologous recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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