Thermo Fisher Scientific CD254 (RANK Ligand) Polyclonal Antibody
RANK Ligand을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응. Western blot과 IHC에 사용 가능하며, Protein G로 정제된 액상형 항체. 연구용으로만 사용.
- 카탈로그번호
- PA141318
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.5 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues A(161) Q P F A H L T I N A A S I P S G(177) of mouse RANK-L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1087028 |
Target Information
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
It acts as a dendritic cell survival factor and is involved in the regulation of T cell-dependent immune responses.
T cell activation induces expression of this gene, leading to increased osteoclastogenesis and bone loss.
It activates antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation.
Targeted disruption in mice causes severe osteopetrosis and absence of osteoclasts, with defects in T/B lymphocyte differentiation and mammary gland development.
Two alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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