Thermo Fisher Scientific FBXO8 Monoclonal Antibody (OTI3C5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Target Information

This gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid motif called the F-box. F-box proteins form one of the four subunits of the ubiquitin protein ligase complex (SCFs: SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.
F-box proteins are divided into three classes:

• Fbws containing WD-40 domains
• Fbls containing leucine-rich repeats
• Fbxs containing either different protein-protein interaction modules or no recognizable motifs

The protein encoded by this gene belongs to the Fbxs class and contains a C-terminal amino acid sequence similar to a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s) (ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.