Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (MYC909)

Applications and Tested Dilution

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK has been linked to cell proliferation and cycle regulation. c-Myc is essential for vasculogenesis and angiogenesis in tumor development.

The c-myc oncogene (p62 c-Myc) regulates normal cellular proliferation and differentiation, while deregulated expression induces apoptosis in multiple cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins with Myc epitope tags at either amino- or carboxy-termini.

c-Myc, N-Myc, and L-Myc proteins contribute to cell proliferation, differentiation, and neoplastic diseases. Amplification of the c-Myc gene has been detected in various human tumors including lung, breast, and colon carcinomas. N-Myc amplification is common in neuroblastomas. Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders.

Aberrant c-Myc expression occurs in tumors of diverse origins such as colorectal, gastric, hepatic, mammary, ovarian, pulmonary, prostatic, thyroidal, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.