Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (MYC275, MYC909)

Applications and Tested Dilutions

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is functionally associated with cell proliferation and regulation. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, while deregulated expression induces apoptosis in various cell types. Antibodies against c-Myc epitopes recognize Myc-tagged fusion proteins at either the amino- or carboxy-termini.

c-Myc, N-Myc, and L-Myc proteins function in cell proliferation, differentiation, and neoplastic disease. Amplification of the c-Myc gene has been observed in lung, breast, and colon carcinomas, while N-Myc amplification occurs in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-Myc expression is also found in tumors of colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic origins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.