Thermo Fisher Scientific PHD3 Polyclonal Antibody
Thermo Fisher Scientific의 PHD3 Polyclonal Antibody는 인간 단백질에 반응하며 Western blot에 적합합니다. EGLN3 내부 서열을 면역원으로 사용한 염소 다클론 항체로, 액상 형태이며 0.5 mg/mL 농도로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RLGKYYVKERSK) corresponding to internal amino acids of EGLN3 (aa 108–120) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982980 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates specific proline residues in the oxygen-dependent degradation (ODD) domains (NODD and CODD) of HIF1A and HIF2A, with a preference for CODD sites. Hydroxylation enables proteasomal degradation via the von Hippel-Lindau complex. Under hypoxia, hydroxylation is reduced, allowing HIFs to accumulate and activate hypoxia-inducible genes. EGLN3 also regulates apoptosis in cardiomyocytes and neurons, glycolysis via PKM hydroxylation, and DNA damage response by hydroxylating TELO2 to promote ATR/CHK1/p53 pathway activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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